New anthelmintics for livestock: the time is right

Area of Science:

• Veterinary Parasitology
• Anthelmintic Resistance
• Small Ruminant Health

Background:

• Increasing anthelmintic resistance poses a significant threat to the economic viability of small-ruminant farming operations.
• A lack of novel anthelmintic drug classes developed over recent decades, coupled with market skepticism from animal health companies, has exacerbated the problem.

Purpose of the Study:

• To highlight the urgent need for new anthelmintic compounds in veterinary medicine.
• To argue that current market conditions are becoming favorable for the development of new anthelmintics.
• To emphasize the importance of resistance management strategies for ensuring product longevity.

Main Methods:

• This study presents a critical analysis of the current landscape of anthelmintic resistance in ruminants.
• It reviews the market dynamics and commercial considerations for new drug development in animal health.
• It synthesizes information on the prevalence of multiple-drug resistance and the scarcity of alternative control methods.

Main Results:

• Anthelmintic resistance is a growing global concern, severely impacting small ruminant production.
• The market for new anthelmintics is expanding due to increasing multi-drug resistance in nematodes.
• Limited non-chemical control options further drive the demand for effective treatments.

Conclusions:

• A new anthelmintic drug is urgently required to address the escalating resistance crisis in small ruminants.
• The market is receptive to new anthelmintic solutions, offering commercial potential for innovation.
• Implementing robust resistance management strategies will be key to maximizing the lifespan and effectiveness of new products.