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Related Experiment Videos

Selenium and Behçet's disease.

E Delilbaşi1, B Turan, E Yücel

  • 1Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gazi University, Ankara, Turkey.

Biological Trace Element Research
|January 1, 1991
PubMed
Summary
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Patients with Behçet's disease exhibit significantly lower serum selenium levels and altered immunoglobulin G and M concentrations compared to healthy controls. This suggests selenium deficiency may impair the humoral immune response in Behçet's disease.

Area of Science:

  • Immunology
  • Nutritional Science
  • Rheumatology

Background:

  • Behçet's disease is an inflammatory condition with unknown causes, featuring recurrent ulcers and inflammation.
  • Selenium (Se) plays a crucial role in immune system function, with deficiency potentially leading to immunosuppression and supplementation potentially restoring immune functions.
  • The relationship between selenium levels and immune response in Behçet's disease requires further investigation.

Purpose of the Study:

  • To compare serum selenium, immunoglobulin G (IgG), and immunoglobulin M (IgM) levels in patients with Behçet's disease and healthy controls.
  • To investigate the potential link between selenium deficiency and impaired humoral immunity in Behçet's disease.

Main Methods:

  • Serum samples were collected from adult patients diagnosed with Behçet's disease and age-matched healthy controls.

Related Experiment Videos

  • Serum selenium levels were quantified using Atomic Absorption Spectroscopy (AAS).
  • Immunoglobulin G and M levels were determined using the immunodiffusion technique.

    • Main Results:

    • Behçet's disease patients had significantly lower mean serum selenium levels (54.24 ng/mL) compared to controls (90.01 ng/mL) (P < 0.01).
    • Mean serum IgG (10.01 mg/mL) and IgM (1.26 mg/mL) levels were significantly lower in patients than in controls (15.08 mg/mL and 1.58 mg/mL, respectively) (P < 0.05).

    Conclusions:

    • A significant deficiency in serum selenium exists in patients with Behçet's disease.
    • The observed lower levels of immunoglobulins (IgG and IgM) suggest that selenium deficiency may impede the humoral immune response in this condition.
    • Further research into selenium supplementation for Behçet's disease patients is warranted.