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Related Concept Videos

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

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Related Experiment Video

Updated: Jul 18, 2026

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
08:08

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

Published on: February 27, 2015

[Proteomics and breast cancer].

C Mathelin1, C Tomasetto, A Cromer

  • 1Service de gynécologie-obstétrique, CHRU de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg cedex, France. carole.mathelin@chru-strasbourg.fr

Gynecologie, Obstetrique & Fertilite
|November 25, 2006
PubMed
Summary

Proteomic approaches analyze protein changes in breast cancer. Surface-Enhanced Laser Desorption/Ionization Time-Of-Flight Mass Spectrometry (SELDI-TOF MS) shows promise for discovering biomarkers for early detection and improved patient management.

More Related Videos

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
10:37

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

Related Experiment Videos

Last Updated: Jul 18, 2026

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
08:08

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

Published on: February 27, 2015

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
10:37

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

Area of Science:

  • Proteomics
  • Biochemistry
  • Oncology

Context:

  • Breast cancer is a leading cause of death in women aged 35-55.
  • Tumor progression involves genetic and gene expression alterations, impacting protein profiles.
  • Proteomic approaches enable global and comparative analysis of proteins in normal and cancerous tissues.

Purpose:

  • To present common proteomic methods used in breast cancer research.
  • To review initial findings from proteomics studies applied to breast cancer.
  • To highlight results obtained using Surface-Enhanced Laser Desorption/Ionization Time-Of-Flight Mass Spectrometry (SELDI-TOF MS).

Summary:

  • Proteomics studies in breast cancer can analyze either the tumor proteome or blood-derived proteome.
  • Tumor proteome studies aim to globally understand the disease.
  • Blood proteome studies focus on discovering serum biomarkers for early detection, diagnosis, prognosis, and management.

Impact:

  • Emerging proteomic methods yield promising results in breast cancer research.
  • Novel biomarkers identified through proteomics require future validation.
  • These validated biomarkers are expected to significantly impact breast cancer patient management.