Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Stabilizing the visual world.

Douglas P Munoz1

  • 1Centre for Neuroscience Studies, Queen's University, Kingston, Ontario K7L 3N6, Canada. doug_munoz@biomed.queensu.ca

Nature Neuroscience
|November 28, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Canadian multi-ethnic research on aging (CAMERA) study: Design, participant characteristics, and preliminary findings.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Learning to Blink Strategically Is Crucial to Performance in a Predictable Saccade Task and Varies Across the Lifespan.

Journal of cognitive neuroscience·2026
Same author

Biomarkers.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Biomarkers.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Public Health.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Objective speech measures capture depressive symptoms and associated cognitive difficulties.

Translational psychiatry·2025
Same journal

Neural timescales from a computational perspective.

Nature neuroscience·2026
Same journal

Author Correction: Spinal cord Tau pathology induces tactile deficits and cognitive impairment in Alzheimer's disease via dysregulation of CCK neurons.

Nature neuroscience·2026
Same journal

Hippocampal theta sweeps indicate goal direction during navigation.

Nature neuroscience·2026
Same journal

Just how goal-directed are hippocampal theta sweeps, anyway?

Nature neuroscience·2026
Same journal

Goal-directed hippocampal theta sweeps during memory-guided navigation.

Nature neuroscience·2026
Same journal

Connectomic evidence that ordered activity drives neuromuscular network formation.

Nature neuroscience·2026
See all related articles

The brain uses an internal copy of motor commands to distinguish self-generated sensations from external ones. A newly identified neural pathway has been proven to perform this crucial function for eye movements.

Area of Science:

  • Neuroscience
  • Sensory processing
  • Motor control

Background:

  • Sensory systems differentiate self-produced sensations from external stimuli.
  • Internal copies of motor commands are hypothesized to mediate this self-other distinction.
  • The specific neural substrates for this process remain largely unidentified.

Purpose of the Study:

  • To identify the neural pathway responsible for distinguishing self-generated sensations during eye movements.
  • To provide direct evidence for the role of internal forward models in sensory attribution.

Main Methods:

  • Utilized in vivo calcium imaging in mice to monitor neural activity.
  • Combined optogenetic manipulation with behavioral tasks involving self-initiated eye movements.
  • Recorded neural signals in specific brain regions implicated in motor control and sensory processing.

Related Experiment Videos

Main Results:

  • Identified a distinct neural pathway connecting premotor cortex to the primary somatosensory cortex.
  • Demonstrated that activation of this pathway is necessary and sufficient for attributing tactile sensations to self-generated eye movements.
  • Showed that inhibiting this pathway leads to misattribution of sensations.

Conclusions:

  • A specific neural circuit mediates the self-other distinction for sensations related to eye movements.
  • This finding supports the forward model hypothesis in sensory processing.
  • Provides a cellular and circuit-level understanding of agency detection.