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Updated: Jul 18, 2026

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

Infusion reactions and their management.

Lloyd Mayer¹, Yuki Young

¹Division of Gastroenterology and Clinical Immunology, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1089, New York, NY 10029, USA. lloyd.mayer@mssm.edu

Gastroenterology Clinics of North America

|November 30, 2006

Summary

Optimize infliximab therapy to reduce anti-drug antibodies (ADA) and infusion reactions. Strategies include induction therapy, concurrent immunomodulators, and steroid premedication for sustained clinical response.

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Last Updated: Jul 18, 2026

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

Area of Science:

Immunology
Pharmacology
Clinical Medicine

Background:

Infliximab therapy requires optimization to mitigate immunogenicity and infusion reactions.
Minimizing anti-drug antibodies (ADA) is crucial for maintaining clinical efficacy.
Infusion reactions are common and necessitate management protocols.

Purpose of the Study:

To outline evidence-based strategies for optimizing infliximab therapy.
To detail methods for minimizing infliximab immunogenicity and infusion reactions.
To provide guidance on managing infusion reactions during infliximab treatment.

Main Methods:

Review of best available evidence on infliximab therapy optimization.
Administration of infliximab with multidose induction and scheduled maintenance.
Concurrent use of immunomodulators and potential steroid premedication.

Main Results:

Multidose induction therapy and scheduled maintenance minimize ADA formation.
Concurrent immunomodulators reduce immunogenicity and improve response rates.
Steroid premedication may further reduce infusion reactions.

Conclusions:

Optimized infliximab dosing and concurrent therapies enhance treatment efficacy.
Proactive management of immunogenicity and infusion reactions is essential.
Adherence to specific protocols ensures safe and effective infliximab use.