Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Natural antisense transcripts.

Andreas Werner1

  • 1Institute for Cell and Molecular Biosciences, The Medical School, Framlington Place, University of Newcastle, Newcastle upon Tyne, UK. andreas.werner@ncl.ac.uk

RNA Biology
|November 30, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Disruption of Epidemic Patterns in Community-Acquired Respiratory Infections Post-Covid-19 in France: A 5-Year Analysis Using the French Pediatric and Ambulatory Research of Infectious Diseases Network.

The Pediatric infectious disease journal·2025
Same author

Impact of Respiratory Syncytial Virus Immunization on the Rate of Pediatric Acute Otitis Media: A Time-series Analysis.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2025
Same author

Diagnostic value of preoperative joint aspiration for periprosthetic shoulder infection: analysis of microbiological aspects and preoperative ICM minor criteria.

Archives of orthopaedic and trauma surgery·2025
Same author

Characteristics of Children Hospitalized for Acute COVID-19 in France From February 2020 to December 2023.

The Pediatric infectious disease journal·2025
Same author

Did the resurgence of childhood lower respiratory infections offset the initial benefit of COVID-19-related non-pharmaceutical interventions in children? A time-series analysis.

BMC medicine·2025
Same author

Comparing NIRS and Pulse Oximetry for Cerebral Oxygen Saturation During Hypoxia Testing.

Medical sciences (Basel, Switzerland)·2024
Same journal

RNA polymerase II phosphorylation dynamics: from molecular mechanisms to human disease.

RNA biology·2026
Same journal

Impact of interspecies colostrum and milk replacement on circulating sncRNA dynamics of neonatal goat kids.

RNA biology·2026
Same journal

The role of RNA modifications in cancer translational control.

RNA biology·2026
Same journal

Discovery of a mutation-containing circRNA in polyglutamine disease through systematic analysis of RNAs with CAG repeats.

RNA biology·2026
Same journal

FDA-approved antisense oligonucleotide therapies for duchenne muscular dystrophy: current status and future outlook.

RNA biology·2026
Same journal

The RNA binding protein ZFP36L2 displays tissue-selective mRNA targeting in mice.

RNA biology·2026
See all related articles

Natural antisense transcripts, arising from overlapping genes, are widespread but their function is unclear. Research suggests at least two distinct categories of these RNA molecules with different biological roles.

Area of Science:

  • Genomics
  • Molecular Biology
  • RNA Biology

Background:

  • Whole genome sequencing reveals approximately 20% of human and mouse genes overlap, forming potential sense and antisense transcript pairs.
  • Experimental evidence increasingly supports the existence and prevalence of experimentally identified antisense transcripts across species.

Purpose of the Study:

  • To investigate the physiological relevance and biological functions of natural antisense transcripts.
  • To explore the potential mechanisms and categorize different types of natural antisense transcripts.

Main Methods:

  • Genomic studies analyzing overlapping gene structures.
  • Experimental identification and characterization of antisense transcripts.

Main Results:

Related Experiment Videos

  • Natural antisense transcripts are a widespread phenomenon in RNA-mediated gene regulation.
  • Genomic studies suggest duplex formation between sense and antisense transcripts is crucial for biological function.
  • Antisense transcripts are implicated in imprinting, X-chromosome inactivation, and genomic rearrangements in leukocytes.

Conclusions:

  • The physiological relevance of natural antisense transcripts is not fully understood, despite their widespread nature.
  • At least two distinct categories of natural antisense transcripts exist, differing in biological function and regulatory mechanisms.
  • While some antisense transcripts are linked to mono-allelic expression phenomena, many predicted transcripts may have other roles.