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[Ciprofloxacin concentration in human prostatic tissue following 3 days' administration]
M Morita1, H Nakagawa, K Suzuki
1Department of Urology, Sendai Social Insurance Hospital.
Hinyokika Kiyo. Acta Urologica Japonica
|May 1, 1991
Summary
Ciprofloxacin (CPFX) effectively penetrates prostatic tissue, with higher concentrations observed closer to the final dose. This antibiotic shows promise for treating prostate infections in patients with benign prostatic hypertrophy.
Area of Science:
- Pharmacology
- Urology
- Drug Metabolism
Context:
- Benign prostatic hypertrophy (BPH) affects a large number of aging men.
- Prostatic infections can complicate BPH management.
- Effective antibiotic penetration into prostatic tissue is crucial for treatment success.
Purpose:
- To investigate the penetration of Ciprofloxacin (CPFX) into prostatic tissue and serum.
- To determine the relationship between drug administration timing and tissue concentration.
- To assess CPFX levels in patients undergoing transurethral resection of the prostate (TURP).
Summary:
- Forty-four patients with BPH received oral Ciprofloxacin (200 mg TID) for three days preoperatively.
- Prostatic tissue and serum samples were collected at approximately 17 hours (Group 1, n=16) and 5.5 hours (Group 2, n=28) after the final dose.
- Mean CPFX concentrations were significantly higher in prostatic tissue (1.32 µg/g) and serum (0.65 µg/ml) at 5.5 hours compared to 17 hours (0.61 µg/g and 0.27 µg/ml, respectively).
Impact:
- Demonstrates favorable Ciprofloxacin penetration into prostatic tissue.
- Suggests optimal therapeutic levels are achieved within hours of the last dose.
- Provides valuable pharmacokinetic data for guiding antibiotic therapy in urological infections.