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Related Concept Videos

Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...

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Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model
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Published on: November 4, 2022

[A CASE OF PROSTATE CANCER COMPLICATED BY PELVIC INSUFFICIENCY FRACTURES].

Masato Nozawa1, Hiroshi Fujiwara1, Yasushi Takashima1

  • 1The Department of Urology, Shizuoka City Shizuoka Hospital.

Hinyokika Kiyo. Acta Urologica Japonica
|June 30, 2026
PubMed
Summary
This summary is machine-generated.

This case study highlights radiotherapy-related pelvic insufficiency fractures (PIFs) in a prostate cancer patient. Such fractures are rare but important complications to recognize following pelvic radiotherapy.

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Published on: March 6, 2018

Area of Science:

  • Oncology
  • Radiotherapy
  • Urology

Background:

  • High-risk prostate cancer (pT3bN1Gleason score 4+5) requires aggressive treatment.
  • Castration-resistant prostate cancer (CRPC) necessitates advanced therapies like enzalutamide.
  • Pelvic insufficiency fractures (PIFs) are known complications of pelvic radiotherapy, particularly in gynecologic malignancies.

Purpose of the Study:

  • To report a rare case of pelvic insufficiency fractures (PIFs) in a prostate cancer patient.
  • To analyze the incidence and characteristics of PIFs following pelvic radiotherapy for prostate cancer.
  • To discuss the clinical implications and management of PIFs in this patient population.

Main Methods:

  • A case report of a 63-year-old male with high-risk prostate cancer treated with robot-assisted radical prostatectomy and adjuvant therapy.
  • Review of institutional cases of pelvic fractures after pelvic radiotherapy for prostate cancer.
  • Literature review on PIFs in prostate cancer patients.

Main Results:

  • The patient developed CRPC with bone metastases, treated with enzalutamide and radiotherapy.
  • Radiotherapy led to pelvic insufficiency fractures (PIFs) in the iliac and sacroiliac joints.
  • PIFs are infrequently reported in prostate cancer patients compared to gynecologic malignancies.

Conclusions:

  • Pelvic insufficiency fractures (PIFs) are a potential complication of pelvic radiotherapy in prostate cancer patients.
  • Increased awareness and further research are needed to understand PIF risk and management in prostate cancer.
  • This case underscores the importance of considering PIFs in patients with pelvic radiotherapy history presenting with bone pain.