[A CASE OF PROSTATE CANCER COMPLICATED BY PELVIC INSUFFICIENCY FRACTURES]

Area of Science:

• Oncology
• Radiotherapy
• Urology

Background:

• High-risk prostate cancer (pT3bN1Gleason score 4+5) requires aggressive treatment.
• Castration-resistant prostate cancer (CRPC) necessitates advanced therapies like enzalutamide.
• Pelvic insufficiency fractures (PIFs) are known complications of pelvic radiotherapy, particularly in gynecologic malignancies.

Purpose of the Study:

• To report a rare case of pelvic insufficiency fractures (PIFs) in a prostate cancer patient.
• To analyze the incidence and characteristics of PIFs following pelvic radiotherapy for prostate cancer.
• To discuss the clinical implications and management of PIFs in this patient population.

Main Methods:

• A case report of a 63-year-old male with high-risk prostate cancer treated with robot-assisted radical prostatectomy and adjuvant therapy.
• Review of institutional cases of pelvic fractures after pelvic radiotherapy for prostate cancer.
• Literature review on PIFs in prostate cancer patients.

Main Results:

• The patient developed CRPC with bone metastases, treated with enzalutamide and radiotherapy.
• Radiotherapy led to pelvic insufficiency fractures (PIFs) in the iliac and sacroiliac joints.
• PIFs are infrequently reported in prostate cancer patients compared to gynecologic malignancies.

Conclusions:

• Pelvic insufficiency fractures (PIFs) are a potential complication of pelvic radiotherapy in prostate cancer patients.
• Increased awareness and further research are needed to understand PIF risk and management in prostate cancer.
• This case underscores the importance of considering PIFs in patients with pelvic radiotherapy history presenting with bone pain.