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A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
Published on: January 11, 2020
ADCS Prevention Instrument Project: the Mail-In Cognitive Function Screening Instrument (MCFSI)
Sally P Walsh1, Rema Raman, Katherine B Jones
1Department of Neurology, Georgetown University Medical Center, Washington, DC 20057, USA.
Alzheimer Disease and Associated Disorders
|December 1, 2006
Summary
The Mail-In Cognitive Function Screening Instrument (MCFSI) effectively screens for cognitive decline in older adults. This tool aids in Alzheimer's Disease (AD) prevention trials by identifying individuals needing further evaluation.
Area of Science:
- Neuroscience
- Gerontology
- Clinical Trials
Background:
- Alzheimer's Disease (AD) prevention research requires cost-effective assessment tools for large populations.
- Large, simple trials necessitate low-cost, regular assessments, often via mail.
Purpose of the Study:
- To evaluate the Mail-In Cognitive Function Screening Instrument (MCFSI) as a specific and sensitive tool.
- To determine if MCFSI can serve as a trigger for diagnostic evaluation in AD prevention trials.
Main Methods:
- Developed the MCFSI with 14 questions for subjects and study partners, assessing functional decline.
- Collected baseline data from 640 non-demented subjects in a simulated AD prevention trial.
- Analyzed MCFSI scores in relation to demographic, clinical, and genetic factors.
Main Results:
- Significant differences in MCFSI scores were observed across sex, ethnic, and age groups.
- MCFSI scores correlated with cognitive performance in non-demented individuals.
- No significant association found between MCFSI scores and apolipoprotein E genotype.
Conclusions:
- The MCFSI captures cognitive and functional status information in non-demented elderly individuals.
- The Alzheimer's Disease Cooperative Study Prevention Instrument Project will further assess MCFSI's utility in AD primary prevention trials.
