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Preparation and biological studies of 125I-DOTA-TATE
Aruna Korde1, Usha Pandey, Sharmila Banerjee
1Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai 400 085, India.
Abstract:
DOTA-TATE, a somatostatin analog was radiolabeled with (125)I in good yields and high radiochemical purity. The product exhibited good stability in vitro. Pharmacokinetic studies in normal Swiss mice showed rapid blood clearance with low thyroid uptake. Biodistribution studies in murine melanoma showed 3.0+/-1.3% ID/g uptake in tumor at 3h post injection (p.i.), with negligible reduction at 24h p.i. Inhibition studies carried out in vivo using cold DOTA-TATE confirmed the tumor specificity of the product.
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