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Do antireflux operations decrease the rate of reflux-related hospitalizations in children?
Adam B Goldin1, Robert Sawin, Kristy D Seidel
1Division of Pediatric General and Thoracic Surgery, Children's Hospital and Regional Medical Center, W-7729, PO Box 5371, Seattle, WA 98105-0371, USA. adam.goldin@seattlechildrens.org
Insights
Pediatric antireflux procedures significantly reduced hospitalizations in children under 4. However, older children, especially those with developmental delay, did not show similar benefits, indicating a need for clearer indications.
Area of Science:
- Pediatric Surgery
- Gastroenterology
- Public Health
Background:
- Gastroesophageal reflux disease (GERD) is common in children.
- Antireflux procedures are increasingly performed in pediatric patients.
- The effectiveness of these procedures in reducing hospitalizations needs evaluation.
Purpose of the Study:
- To determine if pediatric antireflux procedures decrease reflux-related hospitalizations.
- To analyze the association between antireflux procedures and hospitalization rates.
- To identify factors influencing the outcomes of these procedures.
Main Methods:
- Retrospective study using Washington State hospital and vital records (1987-2001).
- Identified pediatric patients (<19 years) undergoing antireflux procedures.
- Calculated hospitalization rates before and after procedures, stratified by age.
Main Results:
- 1142 pediatric patients underwent antireflux procedures.
- Procedures showed benefit in children <4 years, with reduced hospitalizations.
- Benefit was less clear for children >4 years; those with developmental delay had higher post-procedure event rates.
Conclusions:
- Antireflux procedures are beneficial for children under 4.
- Effectiveness is questionable in older children, particularly those with developmental delay.
- Clearer indications for antireflux procedures in pediatric populations are needed.
Objective:
Gastroesophageal reflux disease is extremely common in the pediatric population, and antireflux procedures are performed with increasing frequency. The objective of this study was to determine whether pediatric antireflux procedures are associated with a decreased rate of reflux-related hospitalizations.
Methods:
A study was conducted of pediatric patients who were undergoing antireflux procedures using data that were derived from the Washington State Comprehensive Hospital Abstract Reporting System and Vital Records. Patients were identified by a search of all records (1987-2001) for procedure codes that pertained to antireflux procedures in patients who were younger than 19 years. The number of hospitalizations for and rates of reflux-related events per patient-year before and after an antireflux procedure was calculated, and factors that were associated with higher antireflux procedure rates were examined.
Results:
A total of 1142 patients underwent antireflux procedures. The rate of reflux-related events declined sharply with age both before and after an antireflux procedure. The cohort was divided into 3 groups on the basis of age at first antireflux procedure (<1 year, 1-3 years, or 4-19 years), and the calculations of incidence rate ratios before to after an antireflux procedure were done within the same age strata. Results suggest an overall benefit of antireflux procedures in young children. For antireflux procedures that were performed in children who were older than 4 years, the benefit is less clear. Developmental delay was significantly associated with higher rates of reflux-related events among patients who underwent an antireflux procedure after age 4.
Conclusions:
The rate of reflux-related events was lower after an antireflux operation for children who underwent an antireflux procedure before age 4. Older children, however, were hospitalized at equal rates before and after an antireflux procedure, and older children with developmental delay were hospitalized at greater rates after an antireflux procedure. These findings highlight the need to clarify the subjective and objective indications for antireflux procedures in infants and children.
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