Related Experiment Video

Updated: Jul 18, 2026

Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice
06:39

Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice

Published on: April 13, 2015

Cibenzoline improves coronary flow velocity reserve in patients with hypertrophic obstructive cardiomyopathy

Tai Sekine1, Masao Daimon, Rei Hasegawa

  • 1Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.

Heart and Vessels
|December 5, 2006
PubMed

Insights

Cibenzoline improves coronary flow velocity reserve (CFVR) in hypertrophic obstructive cardiomyopathy (HOCM) patients by reducing left ventricular outflow tract pressure gradient (LVPG). This drug offers a dual benefit for HOCM patients with impaired coronary circulation.

Area of Science:

  • Cardiology
  • Pharmacology
  • Echocardiography

Background:

  • Hypertrophic cardiomyopathy (HCM) can lead to impaired coronary circulation.
  • Left ventricular outflow tract obstruction (LVOTO) is a key feature in hypertrophic obstructive cardiomyopathy (HOCM).
  • Coronary flow velocity reserve (CFVR) is a measure of coronary microvascular function.

Purpose of the Study:

  • To investigate the effect of cibenzoline, a class-Ia antiarrhythmic drug, on CFVR in patients with HOCM and hypertrophic nonobstructive cardiomyopathy (HNCM).
  • To assess the relationship between CFVR and left ventricular pressure gradient (LVPG) in HOCM.
  • To determine if cibenzoline can improve coronary circulation in HOCM.

Main Methods:

  • Transthoracic Doppler echocardiography was used to assess CFVR.
  • CFVR was measured before and after intravenous cibenzoline administration (1 mg/kg).
  • Coronary hyperemia was induced using adenosine triphosphate; CFVR was calculated as the ratio of hyperemic to basal mean coronary diastolic flow velocity.

Main Results:

  • Baseline CFVR correlated with LVPG in HOCM patients (r = 0.67, P < 0.03).
  • Cibenzoline significantly improved CFVR (2.0 to 3.0, P < 0.001) and reduced LVPG (55 to 23 mmHg, P < 0.001) in HOCM patients.
  • CFVR remained unchanged in HNCM patients after cibenzoline administration (2.6 to 2.9, P not significant).

Conclusions:

  • Cibenzoline effectively reduces LVPG and improves CFVR in HOCM patients.
  • Left ventricular outflow obstruction significantly contributes to impaired coronary circulation in HOCM.
  • Cibenzoline demonstrates potential therapeutic value for improving coronary function in HOCM.

Related Concept Videos

Heart Failure Drugs: &#946;-Blockers01:22

Heart Failure Drugs: β-Blockers

β-adrenergic antagonists, commonly known as β-blockers, block the effects of sympathetic neurotransmitters such as noradrenaline (NA) and adrenaline (ADR). They have several beneficial effects in heart failure treatment. They reduce heart rate, the force of contraction, and cardiac muscle relaxation. They also slow the atrial-ventricular conduction rate and raise the threshold for arrhythmias. The concentration of β-blockers determines their effects on bronchodilation, vasodilation, and...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...