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Comparative in vitro evaluation of microspherical embolisation agents.

Andrew L Lewis1, Clementine Adams, Wendy Busby

  • 1Biocompatibles UK Ltd, Farnham Business Park, Weydon Lane, Farnham, Surrey, GU9 8QL, UK. andrew.lewis@biocompatibles.com

Journal of Materials Science. Materials in Medicine
|December 5, 2006
PubMed
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This study compared four embolization microspheres, finding significant differences in compressibility and suspension time. Bead Block demonstrated optimal catheter deliverability, highlighting physical properties

Area of Science:

  • Biomaterials Science
  • Interventional Radiology
  • Medical Device Engineering

Background:

  • Microspherical embolization products are crucial in minimally invasive vascular procedures.
  • Understanding the comparative performance of commercially available products is essential for optimizing treatment outcomes.
  • Key performance indicators include mechanical properties, suspension characteristics, and biocompatibility.

Purpose of the Study:

  • To conduct a comparative in vitro evaluation of four commercially available microspherical embolization products: Embosphere, Embogold, Contour SE, and Bead Block.
  • To assess mechanical properties (compressibility, recoverability), suspension behavior with contrast agent, catheter deliverability, and biological characteristics (pro-thrombotic potential).

Main Methods:

  • In vitro mechanical testing to determine compression forces and recoverability.

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  • Suspension studies evaluating equilibrium time with contrast agent.
  • Catheter deliverability assessments using different microsphere-catheter combinations.
  • Scanning Electron Microscopy (SEM) for blood-contacting surfaces and plasma coagulation time assays to evaluate thrombogenicity.

    • Main Results:

    • All tested microspheres exhibited similar size distributions.
    • Contour SE was significantly more compressible (5 kPa) than Embosphere, Embogold, and Bead Block (21-27.5 kPa), but had slower recoverability.
    • Bead Block remained in suspension twice as long as other products, and showed optimal deliverability with the Progreat catheter.
    • None of the products demonstrated pro-thrombotic or pro-coagulatory activity in blood contact and plasma coagulation tests.

    Conclusions:

    • Physical properties, particularly compressibility and suspension behavior, vary among embolization microspheres.
    • These differences can influence delivery mechanics and the effectiveness of vessel occlusion.
    • Bead Block shows promising characteristics for embolization procedures, especially regarding deliverability.