Glucose metabolism in the late preterm infant

Prematurity and low birth weight are important determinants of neonatal morbidity and mortality. A rising trend of preterm births is caused by an increase in the birth rate of near-term infants. Near-term infants are defined as infants of 34 to 36 6/7 weeks gestation. It is dangerous to assume that the incidence of hypoglycemia in the later preterm infant is similar to the infant born at full term. Although current methods for assessing effects of hypoglycemia are imperfect, the injury to central nervous system depends on the degree of prematurity, presence of intrauterine growth restriction (IUGR), intrauterine compromise, genotype, blood flow, metabolic rate, and availability of other substrates. Therefore, early recognition of glucose metabolic abnormalities pertaining to late preterm infants is essential to provide appropriate and timely interventions in the newborn nursery. Although many of the investigations have targeted full-term infants, premature infants inclusive of the extremely low birth weight infants and the intrauterine growth-restricted infants, adequately powered studies restricted to only the late preterm infants are required and need future consideration.