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Metal ion binding of substituted pyrimidine base pairs in DNA duplexes
Yuko Watanabe1, Takahiro Minowa, Akira Ono
1Department of Chemistry, Graduate School and Faculty of Science, Tokyo Metropolitan University, 1-1 Minami-ohsawa, Hachioji, Tokyo 192-0397, Japan.
Abstract:
DNA duplexes containing 5-substituted uracil pairs and N4-substituted cytosine pairs have been chemically prepared and interactions between the duplexes and metal ions have been investigated. Substitutions at the 5-position with the electron withdrawing groups, such as bromo, fluoro and cyano groups, largely alter the binding selectivity of the duplexes and the metal ions.
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