Related Experiment Video
Updated: Jul 18, 2026

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives
Published on: February 7, 2017
Synergistic stabilization of triplex by combination of comb-type cationic copolymer and 2',4'-BNA
Takuma Katayama1, Atsushi Maruyama, Satoshi Obika
1Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, 1-3 Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan.
Abstract:
We examined the effect of the combination of the two triplex-stabilizing factors, poly(L-lysine)-graft-dextran (PLL-g-Dex) copolymer and 2'-O,4'-C-methylene bridged nucleic acid (2',4'-BNA) backbone modification of triplex-forming oligonucleotide (TFO), on the pyrimidine motif triplex formation at neutral pH, a condition where pyrimidine motif triplexes are unstable. The combination of both stabilizing factors that was the triplex involving the 2',4'-BNA TFO in the presence of the copolymer synergistically increased the thermal stability of the pyrimidine motif triplex at neutral pH. The present results certainly support the idea that the combination of the stabilizing factors can be a key method for triplex stabilization and may lead to progress in therapeutic applications of the antigene strategy in vivo.
Related Concept Videos
Cationic Chain-Growth Polymerization: Mechanism
Anionic Chain-Growth Polymerization: Overview
Anionic Chain-Growth Polymerization: Mechanism
Characteristics and Nomenclature of Copolymers
Complexation Equilibria: The Chelate Effect
Step-Growth Polymerization: Overview
Many natural and synthetic polymers are produced by...

