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Updated: Jul 18, 2026

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Gene-therapy Inspired Polycation Coating for Protection of DNA Origami Nanostructures
Published on: January 19, 2019
Improved performance of a DNA nanomachine by cationic copolymers
Naoki Makita1, Satoru Inoue, Toshihiro Akaike
1Department of Biomolecular Engineering, Graduate School of Biosdence and Biotechnology, Tokyo Institute of Technology.
Nucleic Acids Symposium Series (2004)
|December 8, 2006
Abstract:
We have reported previously that the cationic comb-type copolymer, PLL-g-Dex, accelerated DNA strand exchange reaction while stabilizing DNA duplexes. In this research, we studied the effects of PLL-g-Dex on a DNA-fueled nanomachine. The copolymer enabled rapid and secure operations of the DNA nanomachine which utilized the structural transition between intramolecular G-quadruplex and intermolecular double helix.

