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Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures
Published on: June 26, 2020
Synthesis and alternate-stranded triple helix forming ability of novel anthraquinone modified alpha-beta chimeric DNA
Tomohisa Moriguchi1, A T M Zafrul Azam, Kazuo Shinozuka
1Department of Chemistry, Gunma University, 1-5-1 Tenjincho, Kiryu, Gunma 376-8515, Japan.
Abstract:
A series of novel alpha-beta chimeric oligonucleotides bearing an anthraquinone-conjugated non-nucleosidic backbone were synthesized as a triplex-forming oligonucleotide (TFO). UV-melting experiments revealed that the obtained modified chimera TFOs form remarkably stable alternate-stranded triplex almost regardless to the stereochemistry of the incorporated non-nucleosidic backbone unit.
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