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Updated: Jul 18, 2026

In Vitro Selection of Aptamers to Differentiate Infectious from Non-Infectious Viruses
Published on: September 7, 2022
Selection of RNA-aptamer against human influenza B virus
Subash C B Gopinath1, Kazunori Kawasaki, Penmetcha K R Kumar
1Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Central 6, 1-1 Higashi, Tsukuba City 305-8566 Ibaraki, Japan.
Abstract:
Developing specific probes that distinguishes types and subtypes of viruses by a single probe will have a great impact not only in developing specific diagnostic reagents but also in developing tailor-made drugs and dosage requirements depending upon the genotype that cause the infection. We have selected aptamers specific for hemagglutinin protein of human influenza virus B/Johannesburg/05/1999. The selected aptamer, Class A-20, bind specifically to hemagglutinin of B/Johannesburg/05/1999 and able to discriminate it from hemagglutinin of human influenza A virus.
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