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Updated: Jul 18, 2026

Synthesis of Wavelength-shifting DNA Hybridization Probes by Using Photostable Cyanine Dyes
Published on: July 6, 2016
Control of DNA hybridization by photoswitchable mismatch binding ligands
Chikara Dohno1, Shin-nosuke Uno, Kazuhiko Nakatani
1The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki 567-0047, Japan.
Abstract:
We herein demonstrate that mismatch binding ligands (MBL) can function as a molecular glue which brings two single stranded DNA (ssDNA) together to form the double stranded DNA (dsDNA). Incorporation of a photoisomerizable azobenzene linkage provides further ability of reversibly controlling duplex stability with light.
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