Related Experiment Video
Updated: Jul 18, 2026

Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers
Published on: August 12, 2014
Ligand-based vascular targeting of disease
Jascha-N Rybak1, Eveline Trachsel, Jörg Scheuermann
1ETH Zürich, Institute of Pharmaceutical Sciences, Zürich, Switzerland.
Abstract:
This review illustrates the basic principles of ligand-based vascular targeting and presents some of the most advanced results obtained in this field, not only in terms of biopharmaceuticals, which are currently being investigated in clinical and preclinical studies, but also in terms of enabling technologies that facilitate target and ligand discovery. Whereas most of the vascular targeting research activities have so far concentrated on tumoral angiogenesis, the development of non-oncological applications has recently gained momentum and is likely to become an important area of modern pharmaceutical research.
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