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[The comparison study of glaucoma trabeculectomy applying amniotic membrane or mitomycin C]
Kangkeng Zheng1, Zicai Huang, Haitang Zou
1Department of Ophthalmology, Shantou Central Hospital, Guangdong Shantou 515031, China.
Yan Ke Xue Bao = Eye Science
|December 15, 2006
Summary
Trabeculectomy with human amniotic membrane (HAM) or mitomycin (MMC) both improve glaucoma surgery success rates. While HAM caused shallow anterior chambers, MMC led to bleb issues, but both methods enhance outcomes.
Area of Science:
- Ophthalmology
- Surgical Innovation
Background:
- Glaucoma treatment often involves surgical intervention to reduce intraocular pressure.
- Trabeculectomy is a common glaucoma surgery, but its efficacy can be enhanced with adjuncts.
- Human amniotic membrane (HAM) and mitomycin (MMC) are used to improve surgical outcomes.
Purpose of the Study:
- To compare the effectiveness of trabeculectomy augmented with human amniotic membrane (HAM) versus mitomycin (MMC) in glaucoma treatment.
- To evaluate the safety and efficacy of HAM and MMC as adjuncts to trabeculectomy.
Main Methods:
- A randomized controlled clinical trial involving 48 eyes of 28 glaucoma patients.
- Patients were divided into two groups: trabeculectomy with HAM transplantation or trabeculectomy with intraoperative MMC administration (0.2-0.4mg/ml for 2-4 minutes).
- Follow-up was conducted over 6 months.
Main Results:
- Both HAM and MMC groups demonstrated higher success rates compared to standard trabeculectomy.
- No significant difference in success rates was observed between the HAM and MMC groups.
- HAM complications included shallow anterior chamber; MMC complications included thin wall bleb, bleb leaking, persistent hypotony, and hypotonous maculopathy.
Conclusions:
- Proper application of HAM or MMC can improve trabeculectomy success rates.
- Both adjuncts contribute to maintaining functional blebs long-term.
- Utilizing HAM or MMC can lead to a decrease in surgical complications when applied correctly.
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