Related Experiment Video
Updated: Jul 18, 2026
Sub-Retinal Delivery of Human Embryonic Stem Cell Derived Photoreceptor Progenitors in rd10 Mice
Published on: October 6, 2023
[The retinoid acid injected into sub retinal space couldn't reverse the retinal degeneration of mouse]
Liang Zhang1, Shibo Tang, Bing Huang
1Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.
Purpose:
To study the prevention of retinoid acid (RA) to the retinal degeneration when being injected into sub retinal space.
Methods:
10(-3) mol/L RA and phosphate buffered saline (PBS) were injected into the sub retinal space of 8 retinal degeneration (rd) mice respectively. The eye was analysed under microscopy one month after injection. 12 rd mice sorted as 4 groups were contrast; there were 3 rd mice whose mouse age was 7, 14, 28 days and 3 months respectively in each group.
Results:
The cells in inner nucleus layer had proliferated very much in part of tested eyes at one month. There were no difference between group RA and group PBS.
Conclusions:
The degeneration of retina couldn't be stopped and the degenerated retina couldn't be restored to normal through the injection RA into the sub retinal space of rd mouse.
