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Assessment of de novo Protein Synthesis Rates in Caenorhabditis elegans
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Poly(ADP-ribose)-polymerase-1 and aging: experimental study of possible relationship on stationary cell cultures
S I Shram1, G A Shilovskii, A N Khokhlov
1Institute of Molecular Genetics, Russian Academy of Sciences. shram@img.ras.ru
Bulletin of Experimental Biology and Medicine
|December 22, 2006
Abstract:
Experiments on "stationary aging" cultures of B11dii-FAF28 Chinese hamster cells showed that contact inhibition of cell growth and further culturing of cells in the stationary phase led to continuous inhibition of enzymes realizing poly-ADP-ribosylation of chromatin proteins. Cell density in the monolayer and percentage of damaged cells detected by trypan blue staining decreases during this process.
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