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Castleman's disease, intermediate type: a case report.
Vandana Raphael1, Raphael H Lyngdoh
1Department of Pathology, NEIGRIHMS, Lawmali, Shillong, Meghalaya 793001.
Indian Journal of Pathology & Microbiology
|December 23, 2006
Summary
Castleman's disease, a rare lymph node hyperplasia, can present with intermediate features. Surgical removal of this cervical lymphadenopathy variant led to symptom relief and no recurrence.
Area of Science:
- Pathology
- Oncology
- Immunology
Background:
- Castleman's disease (CD) is a rare lymphoproliferative disorder.
- Histologically, CD presents as hyaline vascular variant (90% of cases) or plasma cell type (rare).
Observation:
- A 70-year-old male presented with cervical lymphadenopathy.
- The patient exhibited Castleman's disease with intermediate features, combining hyaline vascular and plasma cell elements.
Findings:
- The patient underwent surgical excision for the cervical lymphadenopathy.
- Post-surgery, the patient experienced complete resolution of constitutional symptoms.
Implications:
- This case highlights the existence and successful management of an intermediate variant of Castleman's disease.
- Complete surgical resection is an effective treatment for localized Castleman's disease with intermediate features.
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