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Permanent Cerebral Vessel Occlusion via Double Ligature and Transection
Published on: July 21, 2013
Obstetric cerebral venous thrombosis.
Bhojo A Khealani1, Uzma U Mapari, Rozina Sikandar
1Neurology Section, Department of Medicine, The Aga Khan University, Karachi.
JPMA. the Journal of the Pakistan Medical Association
|December 23, 2006
Summary
Pregnancy and postpartum periods significantly increase the risk of cerebral venous thrombosis due to blood clotting changes. While management is similar to non-pregnancy related cases, the prognosis for pregnancy-associated venous stroke differs.
Area of Science:
- Neurology
- Obstetrics
- Hematology
Background:
- Pregnancy and puerperium are recognized as high-risk prothrombotic states.
- Cerebral venous thrombosis (CVT) is more likely to be of venous origin in strokes associated with pregnancy.
- Physiological changes in the coagulation system during pregnancy persist postpartum, creating a hypercoagulable state.
Purpose of the Study:
- To highlight the increased risk of cerebral venous thrombosis during pregnancy and puerperium.
- To compare the likelihood of venous stroke in pregnancy-associated strokes versus non-pregnant individuals.
- To discuss the distinct prognostic implications of CVT in the context of pregnancy.
Main Methods:
- Review of existing literature on prothrombotic states in pregnancy and puerperium.
- Analysis of stroke etiology in pregnant versus non-pregnant populations.
- Comparison of management and prognostic factors for cerebral venous thrombosis.
Main Results:
- Pregnancy and the postpartum period are major prothrombotic states.
- The incidence of venous stroke is higher in pregnant women compared to the general population.
- Postpartum hypercoagulability is exacerbated by volume depletion, trauma, infection, and instrumental delivery or Cesarean section.
Conclusions:
- Cerebral venous thrombosis is a significant risk during pregnancy and puerperium due to induced hypercoagulability.
- Management principles for CVT are generally consistent with non-pregnant cases.
- The prognosis for pregnancy-associated cerebral venous thrombosis requires specific consideration and differs from non-pregnant cases.
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