Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mismatch Repair01:20

Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
Mismatch Repair01:36

Mismatch Repair

Overview
Huntington Disease l: Introduction01:21

Huntington Disease l: Introduction

Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...
Translation01:31

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adhesive tape loops.

Soft matter·2026
Same author

Protocol for deriving proliferating primary fibroblast cultures from Malabar red snapper larvae for cytogenetic analysis.

STAR protocols·2026
Same author

Cone-beam Computed Tomography Analysis and Rehabilitation of a Rare Case of Bilateral Taurodontism.

Contemporary clinical dentistry·2025
Same author

Smart traceable framework for transportation of transplantable organs using IPFS, iot, and smart contracts.

Scientific reports·2025
Same author

Rare angiofibrolipoma of the oral cavity: a case report.

General dentistry·2025
Same author

Challenges in status disclosure and adherence to antiretroviral therapy in children living with HIV: An observational study.

Indian journal of sexually transmitted diseases and AIDS·2025

Related Experiment Video

Updated: Jul 18, 2026

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
07:15

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

Minimal change disease: a review.

Tapasi C Saha1, Harmeet Singh

  • 1Brody School of Medicine, East Carolina University, 2355 W. Arlington Boulevard, Greenville, North Carolina 37834, USA. sahat@ecu.edu

Southern Medical Journal
|January 2, 2007
PubMed
Summary

Minimal change disease (MCD) is a kidney condition causing nephrotic syndrome, often idiopathic. Corticosteroids are the primary treatment, with other immunosuppressants for resistant cases.

Area of Science:

  • Nephrology
  • Immunology
  • Pathology

Background:

  • Minimal change disease (MCD) is a leading cause of nephrotic syndrome in children and adults.
  • The exact pathogenesis of MCD remains unclear, but T-cell dysregulation is strongly suspected.
  • Massive proteinuria in MCD results in significant complications including hypoalbuminemia, edema, and hyperlipidemia.

Purpose of the Study:

  • To provide a concise overview of Minimal Change Disease.
  • To highlight the diagnostic criteria and therapeutic approaches for MCD.
  • To underscore the importance of understanding MCD's pathophysiology for improved patient outcomes.

Main Methods:

  • Diagnosis relies on characteristic histopathological findings on renal biopsy, considered the gold standard.

More Related Videos

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
09:34

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

Related Experiment Videos

Last Updated: Jul 18, 2026

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
07:15

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
09:34

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

  • Clinical presentation and laboratory findings support the diagnosis.
  • Review of current literature on MCD pathogenesis and treatment.

    • Main Results:

    • Minimal change disease is characterized by nephrotic syndrome with massive proteinuria.
    • Renal biopsy is essential for definitive diagnosis, showing normal glomeruli under light microscopy.
    • MCD demonstrates a high response rate to corticosteroid therapy.

    Conclusions:

    • Minimal change disease is a significant cause of nephrotic syndrome, primarily managed with corticosteroids.
    • While often idiopathic, T-cell involvement is implicated in MCD pathogenesis.
    • Alternative immunosuppressive agents are available for steroid-resistant or frequently relapsing cases.