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Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer
Published on: September 22, 2015
Fabrication of three-dimensional tissues.
Valerie Liu Tsang1, Sangeeta N Bhatia
1Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.
Advances in Biochemical Engineering/Biotechnology
|January 2, 2007
Summary
Tissue engineering aims to restore organ function using scaffolds with precise architectural features. Manufacturing techniques are adapted to create these 3D scaffolds for improved nutrient transport and cellular stability.
Area of Science:
- Biomedical Engineering
- Regenerative Medicine
- Materials Science
Background:
- Tissue engineering seeks to repair or replace damaged organs.
- Engineered tissues require specific macro- and micro-architectural features for functionality.
- Nutrient transport, mechanical stability, and cellular microenvironment are critical.
Purpose of the Study:
- To review 3D fabrication techniques for tissue engineering scaffolds.
- To highlight the adaptation of manufacturing techniques for creating defined scaffold architectures.
- To cover acellular scaffolds, cellular assembly, and hybrid constructs.
Main Methods:
- Review of manufacturing-inspired techniques for scaffold fabrication.
- Analysis of methods for creating 3D architectures at physiologically relevant scales.
- Categorization of techniques into acellular scaffolds, cellular assembly, and hybrid constructs.
Main Results:
- Manufacturing techniques enable the creation of scaffolds with defined 3D architectures.
- These techniques address the need for both macro- and micro-scale features in engineered tissues.
- A range of fabrication approaches, including acellular, cellular, and hybrid methods, are discussed.
Conclusions:
- 3D fabrication techniques are crucial for developing functional engineered tissues.
- Adaptation of manufacturing processes offers advanced solutions for scaffold design.
- The reviewed techniques provide a foundation for future advancements in organ restoration.
