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Related Experiment Videos

FGF10 signaling controls stomach morphogenesis.

Pia Nyeng1, Gitte Anker Norgaard, Sune Kobberup

  • 1Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 E 9th Avenue, Denver, CO 80262, USA.

Developmental Biology
|January 2, 2007
PubMed
Summary
This summary is machine-generated.

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Fibroblast Growth Factor 10 (FGF10) signaling is crucial for maintaining stomach progenitor cells, controlling their development, and differentiation. This study reveals FGF10

Area of Science:

  • Developmental Biology
  • Gastroenterology
  • Cell Biology

Background:

  • Progenitor cell maintenance is essential for organogenesis, particularly for endoderm-derived organs.
  • Fibroblast Growth Factor 10 (FGF10) is known to influence lung and pancreatic development.
  • The specific role of FGF10 in stomach development and progenitor cell regulation remained largely uncharacterized.

Purpose of the Study:

  • To investigate the role of FGF10 signaling in the maintenance, morphogenesis, and differentiation of stomach progenitor cells.
  • To characterize the 'secondary transition' event in mouse stomach development and identify key signaling pathways involved.
  • To elucidate the molecular mechanisms by which FGF10 controls gastric gland specification and progenitor cell fate.

Main Methods:

Related Experiment Videos

  • Characterization of terminal differentiation in mouse forestomach, corpus, and antrum between embryonic day 15.5 and 16.5.
  • Expression analysis of Fibroblast Growth Factor (FGF) and Notch signaling pathway components.
  • Ectopic expression of FGF10 in developing posterior stomach tissues (pPDX-FGF10(FLAG) mice) to assess its functional impact.

    • Main Results:

    • A 'secondary transition' event was identified, involving the differentiation of squamous, parietal, chief, and endocrine cells from progenitor epithelium.
    • Ectopic FGF10 expression disrupted the glandular proliferative niche, leading to aberrant gland formation and attenuated differentiation of endocrine and parietal cells.
    • Changes in Hes1, Sonic hedgehog (Shh), and Wnt6 gene expression were observed, indicating FGF10 interacts with multiple signaling systems.

    Conclusions:

    • FGF10 signaling is a critical regulator of gastric gland specification and progenitor cell maintenance during stomach development.
    • FGF10 plays a significant role in controlling stomach morphogenesis and the differentiation of key gastric cell types.
    • FGF10 functions in conjunction with other morphogenetic signaling pathways, including Notch, Shh, and Wnt, to orchestrate gastric development.