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Related Experiment Videos

HIV and pneumococcal disease.

Keith P Klugman1, Shabir A Madhi, Charles Feldman

  • 1Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA. keith.klugman@emory.edu

Current Opinion in Infectious Diseases
|January 2, 2007
PubMed
Summary
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Highly active antiretroviral therapy (HAART) has lessened pneumococcal disease in HIV-infected adults, but it remains more common. Pneumococcal infections continue to cause significant illness and death in HIV-infected individuals globally.

Area of Science:

  • Infectious Diseases
  • Immunology
  • Public Health

Background:

  • HIV infection significantly increases the risk of pneumococcal disease.
  • Pneumococcal infections pose a substantial global health burden, particularly in HIV-infected populations.

Purpose of the Study:

  • To review the impact of highly active antiretroviral therapy (HAART) on pneumococcal disease burden.
  • To explore advances in understanding HIV's impact on pneumococcal disease.

Main Methods:

  • Literature review of studies on HAART, HIV, and pneumococcal disease.
  • Analysis of epidemiological data and clinical outcomes.

Main Results:

  • HAART has reduced pneumococcal disease in HIV-infected adults, but it remains more prevalent than in HIV-uninfected individuals.

Related Experiment Videos

  • Smoking and comorbidities increase risk among HIV-infected adults. Pneumococcal meningitis is a major burden in Africa without HAART.
  • Conjugate vaccines protect HIV-infected infants, and herd immunity from childhood vaccination reduces disease in HIV-infected adults in the US.

    • Conclusions:

    • Pneumococcus remains a significant cause of morbidity and mortality in HIV-infected children and adults worldwide.
    • Continued vigilance and preventive strategies are crucial for managing pneumococcal disease in this vulnerable population.