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Intracameral Injection in Rats with Low Risk of Adverse Effects
Published on: May 31, 2024
The histopathological effect of intracameral ropivacaine in different concentrations on corneal endothelium
Ihsan Caça1, Vatan Kavak, Kaan Unlü
1Department of Ophthalmology, Dicle University Faculty of Medicine, Diyarbakir, Turkey. ihsancaca@mynet.com
Annals of Ophthalmology (Skokie, Ill.)
|January 4, 2007
Abstract:
We evaluated the histopathological changes occurring in corneal endothelium after intracameral injection ropivacaine into rats. Intracamerally administered ropivacaine in 1, 0.5, and 0.1% concentrations resulted in impairment of hexagonal structure of corneal endothelial cells and intercellular junctions, destruction of microvilli on the cell surface, roughness of cell borders, picnotic nucleus, diffuse vacuolization, and crystalysis in mitochondria.
