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Eucommia ulmoides Oliver leaf extract increases endogenous antioxidant activity in type 2 diabetic mice
Sun Ae Park1, Myung-Sook Choi, Un Ju Jung
1Department of Food and Nutrition, Yeungnam University, Gyeongsan, Republic of Korea.
Journal of Medicinal Food
|January 5, 2007
Summary
Eucommia ulmoides (Du-zhong) leaf extract reduced blood glucose and enhanced antioxidant enzymes in type 2 diabetic mice. This suggests Du-zhong extract may help manage diabetes complications.
Area of Science:
- Pharmacology
- Biochemistry
- Nutrition
Background:
- Type 2 diabetes is a metabolic disorder characterized by hyperglycemia and oxidative stress.
- Oxidative stress plays a crucial role in the development of diabetic complications.
- Natural compounds with antioxidant properties are being explored for their therapeutic potential in diabetes management.
Purpose of the Study:
- To investigate the antioxidant effects of Eucommia ulmoides (Du-zhong) leaf extract in a mouse model of type 2 diabetes.
- To evaluate the impact of Du-zhong extract on blood glucose levels and antioxidant enzyme activities.
- To assess the potential of Du-zhong extract in mitigating oxidative stress associated with type 2 diabetes.
Main Methods:
- Administration of Du-zhong leaf extract (1% of diet) to C57BL/KsJ-db/db mice for 6 weeks.
- Measurement of blood glucose concentrations and plasma paraoxonase activity.
- Assay of antioxidant enzyme activities (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase) in erythrocytes, liver, and kidney.
- Quantification of hydrogen peroxide and lipid peroxide levels.
Main Results:
- Du-zhong extract significantly lowered blood glucose levels and increased plasma paraoxonase activity.
- Erythrocyte antioxidant enzyme activities (SOD, CAT, GSH-Px) were significantly elevated in the Du-zhong group.
- Liver and kidney CAT activity was significantly higher, with reduced levels of hydrogen peroxide and lipid peroxide in Du-zhong treated mice.
- No significant changes were observed in erythrocyte GR activity or SOD, GSH-Px, and GR activities in liver and kidney.
Conclusions:
- Eucommia ulmoides (Du-zhong) leaf extract exhibits significant antioxidant properties in type 2 diabetic mice.
- Du-zhong extract supplementation effectively reduces hyperglycemia and oxidative stress markers.
- These findings suggest that Du-zhong extract holds promise for the prevention and management of type 2 diabetes complications.
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