Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microarray-based analysis of ventilator-induced lung injury.

Mark M Wurfel1

  • 1Division of Pulmonary and Critical Care Medicine, Harborview Medical Center, University of Washington, Seattle, Washington 98104, USA. mwurfel@u.washington.edu

Proceedings of the American Thoracic Society
|January 5, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Independent association between acute kidney injury and kidney function trajectory.

Kidney international·2026
Same author

Urinary angiopoietin-2 is associated with adverse kidney outcomes in the ICU.

Critical care (London, England)·2026
Same author

Racial and Ethnic Disparities in Identification of Cyanosis in ICU Settings.

AMIA ... Annual Symposium proceedings. AMIA Symposium·2026
Same author

Alveolar Immune Profiling Identifies Distinct Subphenotypes of Acute Respiratory Failure.

medRxiv : the preprint server for health sciences·2026
Same author

Anti-CD14 treatment in patients with severe COVID-19: Clinical and biological effects in a Phase 2 randomized open-label adaptive platform clinical trial.

CHEST critical care·2025
Same author

Proteomic Analyses in COVID-19-Associated Secondary Hemophagocytic Lymphohistiocytosis.

Critical care explorations·2025

Mechanical ventilation for acute respiratory distress syndrome (ARDS) can cause lung injury (VILI). Microarray gene expression studies are revealing the molecular mechanisms behind VILI, offering insights for future research.

Area of Science:

  • Pulmonary Medicine
  • Critical Care Medicine
  • Molecular Biology

Background:

  • Acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) are common reasons for ICU admission.
  • Mechanical ventilation, while life-saving, can exacerbate lung injury (VILI) through excessive tidal volumes, increasing mortality.
  • The molecular mechanisms of VILI and its interaction with risk factors like sepsis are not fully understood.

Purpose of the Study:

  • To review recent findings on the molecular mechanisms of ventilator-induced lung injury (VILI).
  • To explore the use of genome-wide gene expression analysis in understanding VILI pathophysiology.
  • To discuss the implications of these findings for future research directions.

Main Methods:

  • Review of recent studies utilizing microarray technology to analyze gene expression in VILI.

Related Experiment Videos

  • Examination of studies investigating VILI in isolation and in conjunction with endotoxin instillation or saline lavage.
  • Analysis of gene expression profiles in epithelial cells subjected to cyclic stretch.

    • Main Results:

    • Microarray analysis provides powerful insights into the molecular mechanisms of VILI.
    • Studies reveal gene expression patterns associated with VILI under various experimental conditions.
    • Cyclic stretch in epithelial cells offers a model for understanding cellular responses in VILI.

    Conclusions:

    • Gene expression profiling is a valuable tool for elucidating VILI pathophysiology.
    • Understanding molecular mechanisms can lead to improved VILI management strategies.
    • Further research is needed to fully unravel VILI's complexities and interactions with clinical risk factors.