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Inducing Cre-lox Recombination in Mouse Cerebral Cortex Through In Utero Electroporation
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Cre/loxP-mediated chromosome engineering of the mouse genome

V Brault1, V Besson, L Magnol

  • 1Institut de Transgénose, IEM, UMR6812, CNRS Uni-Orléans, 3B rue de la Férollerie, 45071 Orleans 2, France.

Handbook of Experimental Pharmacology
|January 6, 2007
PubMed

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To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.