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ST-deviation, C-reactive protein and CPK-MB as mortality predictors in acute myocardial infarction

Mujahid Beg1, Krishna Chand Singhal, Jyoti Wadhwa

  • 1Department of Medicine, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, UP, India. muajhidbeg@rediffmail.com

Nepal Medical College Journal : NMCJ
|January 6, 2007
PubMed

Insights

Early risk stratification using C-reactive protein (CRP), CPK-MB, and ECG ST deviation can predict outcomes in acute myocardial infarction patients. These markers help differentiate between patients who improve and those with adverse events.

Area of Science:

  • Cardiology
  • Biochemistry
  • Medical Diagnostics

Background:

  • Prognosis in acute coronary syndromes is highly variable due to their heterogeneous nature.
  • Early risk stratification is crucial for successful management and improved patient outcomes.
  • Acute myocardial infarction (AMI) requires timely assessment to guide therapeutic decisions.

Purpose of the Study:

  • To evaluate the predictive value of C-reactive protein (CRP) and CPK-MB levels, along with electrocardiogram (ECG) ST deviation, for patient outcomes in AMI.
  • To correlate biochemical markers and ECG findings with patient prognosis following hospital admission for AMI.

Main Methods:

  • A cohort of 120 patients admitted with AMI was studied.
  • Quantitative estimation of C-reactive protein (CRP) and CPK-MB was performed at admission.
  • The number and sum of ECG leads showing ST deviation were calculated and correlated with biochemical markers.
  • Patients were divided into two groups based on final outcome: improvement or expiry.

Main Results:

  • Significant differences were observed in mean CRP and CPK-MB levels between the outcome groups.
  • The number and sum of ECG leads with ST deviation also showed significant differences between patient groups.
  • A significant correlation was found between biochemical markers and the sum of ST deviation in all AMI patients.

Conclusions:

  • CRP, CPK-MB, and ECG ST deviation are valuable indicators for risk stratification in acute myocardial infarction.
  • These early markers can help predict patient outcomes, aiding in management decisions.
  • Combined assessment of biochemical and electrocardiographic data improves prognostic accuracy in AMI.

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