Ketoprofen ion-selective electrode and its application to pharmaceutical analysis

Area of Science:

• Electrochemistry
• Analytical Chemistry

Background:

• Ketoprofen is a widely used non-steroidal anti-inflammatory drug.
• Accurate determination of ketoprofen is crucial for pharmaceutical analysis and quality control.

Purpose of the Study:

• To develop and characterize a novel polymeric potential-determining phase for a ketoprofen-selective electrode.
• To evaluate the electrode's performance for the quantitative determination of ketoprofen.

Main Methods:

• Fabrication of a polymeric membrane electrode using a specific composition.
• Systematic investigation of electrode parameters including measurement range, slope, limit of detection, response time, lifetime, and selectivity.
• Testing the electrode's performance for ketoprofen determination in a specified concentration range.

Main Results:

• The optimal composition of the polymeric potential-determining phase was identified.
• The electrode exhibited a wide measurement range (25.43-25430 microg/mL) for ketoprofen.
• Key electrochemical parameters such as slope, limit of detection, response time, lifetime, and selectivity coefficients were determined and found to be favorable.

Conclusions:

• The developed polymeric phase is suitable for creating a highly selective and sensitive electrode for ketoprofen.
• The novel electrode offers a reliable and efficient method for the quantitative determination of ketoprofen in analytical applications.