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Published on: May 14, 2013

Coronary collateral function long after drug-eluting stent implantation

Pascal Meier1, Rainer Zbinden, Mario Togni

  • 1Department of Cardiology, University Hospital, Bern, Switzerland.

Journal of the American College of Cardiology
|January 9, 2007
PubMed

Insights

Drug-eluting stents (DES) impair coronary collateral function compared to bare-metal stents (BMS) long after implantation. This reduced collateral capacity may increase risks during abrupt coronary occlusion.

Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Biomedical Engineering

Background:

  • Drug-eluting stents (DES) may inhibit growth factors crucial for collateral vessel development.
  • Coronary collateral circulation is vital for preventing ischemia during occlusive events.

Purpose of the Study:

  • To compare coronary collateral function between patients receiving bare-metal stents (BMS) and drug-eluting stents (DES).

Main Methods:

  • 120 patients with stable coronary artery disease post-stenting were analyzed.
  • Collateral flow index (CFI) was invasively measured 6 months post-implantation.
  • Assessment included pressure measurements and intracoronary ECG during balloon occlusion.

Main Results:

  • Coronary collateral flow index (CFI) was significantly lower in the DES group compared to the BMS group.
  • Patients with DES showed a higher incidence of insufficient collaterals to prevent ischemia during occlusion.
  • No significant differences were observed in baseline characteristics or stenosis severity between groups.

Conclusions:

  • Drug-eluting stents (DES) are associated with impaired coronary collateral function compared to bare-metal stents (BMS).
  • Reduced collateral function following DES implantation could increase the risk of adverse cardiac events during acute coronary occlusion.
Abstract

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