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Rupturing polymeric micelles with cyclodextrins.

Julie Joseph1, Cécile A Dreiss, Terence Cosgrove

  • 1University of Bristol, School of Chemistry, Cantock's Close, Bristol BS8 1TS, UK.

Langmuir : the ACS Journal of Surfaces and Colloids
|January 11, 2007
PubMed
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Triblock copolymers (Pluronics) form micelles with increasing temperature. Complexation with heptakis(2,6-di-O-methyl)-beta-cyclodextrin (hbeta-CD) disrupts these micelles, but this effect is temperature-dependent.

Area of Science:

  • Polymer Science
  • Supramolecular Chemistry
  • Materials Science

Background:

  • Triblock copolymers, such as poly(ethylene oxide)-polypropylene oxide-poly(ethylene oxide) (PEO-PPO-PEO), exhibit temperature-dependent self-assembly.
  • These polymers, known as Pluronics, can form micellar structures driven by the hydrophobic interactions of the polypropylene oxide (PPO) block.

Purpose of the Study:

  • To investigate the associative structures of Pluronics using small-angle neutron scattering (SANS).
  • To monitor structural changes upon complexation with heptakis(2,6-di-O-methyl)-beta-cyclodextrin (hbeta-CD) across a temperature range (5–70 °C).

Main Methods:

  • Small-angle neutron scattering (SANS) was employed to analyze polymer aggregation and micelle formation.
  • Temperature-dependent studies were conducted to observe structural transitions and complexation effects.

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Main Results:

  • Pluronics exist as unimers at low temperatures and form spherical micelles (40–50 Å core size) near ambient temperature due to PPO hydrophobicity.
  • hbeta-CD forms pseudopolyrotaxanes with Pluronics, increasing the critical micellar concentration and improving PPO block solubility.
  • Complexation disrupts micelles at moderate temperatures, but this disruption is inhibited above 50 °C, leading to large-scale aggregation.

Conclusions:

  • The self-assembly of Pluronics and their interaction with hbeta-CD are highly temperature-dependent.
  • hbeta-CD can effectively modulate Pluronic micelle formation and stability, with significant implications for their solution behavior.