Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nociception and TRP channels.

M Tominaga1

  • 1Section of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, 444-8787 Okazaki, Japan. tominaga@nips.ac.jp

Handbook of Experimental Pharmacology
|January 16, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Functional analysis of thermo-sensitive TRPV1 in an aquatic vertebrate, masu salmon (<i>Oncorhynchus masou ishikawae</i>).

Biochemistry and biophysics reports·2022
Same author

Betacellulin is downregulated in plaque psoriasis and may reflect disease severity.

Journal of the European Academy of Dermatology and Venereology : JEADV·2022
Same author

Reduction of extracellular sodium evokes nociceptive behaviors in the chicken via activation of TRPV1.

Brain research·2020
Same author

Oral administration of milk-derived phospholipids inhibits penetration of cutaneous nerve fibres into epidermis in a mouse model of acute dry skin.

Clinical and experimental dermatology·2017
Same author

Lafutidine, a histamine H2 receptor antagonist with mucosal protective properties, attenuates 5-fluorouracil-induced intestinal mucositis in mice through activation of extrinsic primary afferent neurons.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2017
Same author

Two different avian cold-sensitive sensory neurons: Transient receptor potential melastatin 8 (TRPM8)-dependent and -independent activation mechanisms.

Neuropharmacology·2016
Same journal

Endothelial Cell Phenotypic Plasticity in Atherosclerosis.

Handbook of experimental pharmacology·2026
Same journal

Endothelial Dysfunction and Neurovascular Alterations in Autism Spectrum Disorder.

Handbook of experimental pharmacology·2026
Same journal

Molecular Mechanisms of Endothelial Shear Stress Mechanotransduction in Health and Disease.

Handbook of experimental pharmacology·2026
Same journal

Microvasculature of the Pancreatic Islets of Langerhans in Health and Diabetes.

Handbook of experimental pharmacology·2026
Same journal

Mechanisms of Actions of Physiological, Pharmacological, and Toxicological Dietary Bioactive Inorganic Boron.

Handbook of experimental pharmacology·2026
Same journal

BNCT Plus Luminescence: New Paradigm for Boron-Containing Drug Design.

Handbook of experimental pharmacology·2026
See all related articles

Transient Receptor Potential (TRP) channels are crucial molecules that convert painful stimuli into electrical signals in specialized nerve cells. These channels play a vital role in detecting noxious stimuli, initiating the pain pathway.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Pain Research

Background:

  • Pain sensation begins when harmful stimuli activate peripheral nerve endings known as nociceptors.
  • Numerous molecules contribute to the transduction of noxious stimuli into electrical signals within nociceptor terminals.

Purpose of the Study:

  • To highlight the significant role of Transient Receptor Potential (TRP) channels in the detection of noxious stimuli.
  • To emphasize the importance of TRP channels in the initial stages of pain signaling.

Main Methods:

  • Review of existing literature on molecular mechanisms of nociception.
  • Analysis of the function of TRP channels in primary afferent neurons.

Main Results:

  • TRP channels are key molecular players in converting noxious stimuli into electrical signals.

Related Experiment Videos

  • These channels are essential for the activation of nociceptors.

    • Conclusions:

    • TRP channels are critical components in the pain pathway, specifically in the detection of noxious stimuli.
    • Understanding TRP channel function is vital for developing novel pain management strategies.