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Effect of barnidipine on blood pressure and serum metabolic parameters in patients with essential hypertension: a

Athanasia Spirou1, Evangelos Rizos, Evangelos N Liberopoulos

  • 1Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece.

Journal of Cardiovascular Pharmacology and Therapeutics
|January 16, 2007
PubMed

Insights

Barnidipine, a calcium channel blocker, effectively lowers blood pressure and reduces oxidative stress markers in hypertensive patients. However, it shows neutral effects on lipid profiles, glucose, and clotting factors, suggesting its primary role as an antihypertensive agent.

Area of Science:

  • Cardiology
  • Pharmacology
  • Metabolic Research

Background:

  • The metabolic effects of barnidipine, a calcium channel blocker, are not fully understood.
  • Essential hypertension management requires evaluation of drug impacts on atherogenesis, oxidative stress, and clotting.

Purpose of the Study:

  • To assess barnidipine's effects on metabolic parameters, oxidative stress, and clotting activity in patients with essential hypertension.
  • To determine if barnidipine influences atherogenic risk factors beyond its blood pressure-lowering effects.

Main Methods:

  • An open-label pilot study involving 40 adult patients with essential hypertension.
  • Patients received barnidipine 10 mg once daily, with assessments of blood pressure, lipid profile, glucose homeostasis, renal function, electrolytes, clotting parameters, and oxidative stress markers (isoprostanes).

Main Results:

  • Barnidipine significantly reduced systolic and diastolic blood pressure and isoprostane levels.
  • No significant changes were observed in lipid profile, apolipoprotein levels, glucose homeostasis, renal function, or electrolyte balance.
  • Clotting/fibrinolytic status and the activity of inflammatory mediators (lipoprotein-associated phospholipase A2, paraoxonase 1) remained unaffected.

Conclusions:

  • Barnidipine is primarily an effective antihypertensive agent with neutral effects on most studied metabolic parameters in hypertensive individuals.
  • Further research is needed to confirm any potential antioxidant effects of barnidipine.

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