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Multicentric peripheral ossifying fibroma.

Satish K S Kumar1, Saravanan Ram, Michael G Jorgensen

  • 1Orofacial Pain and Oral Medicine Center, Division of Diagnostic Sciences, School of Dentistry, University of Southern California., Los Angeles, CA 90089-0641, USA. satish.shyamkumar@usc.edu

Journal of Oral Science
|January 16, 2007
PubMed
Summary
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Peripheral ossifying fibroma (POF) can present as multiple lesions. This unique case suggests a potential multicentric variant of POF, possibly linked to genetic factors.

Area of Science:

  • Oral Pathology
  • Oncology
  • Genetics

Background:

  • Peripheral ossifying fibroma (POF) is a common gingival lesion of unknown etiology.
  • POF is typically solitary, with origins debated between reactive and neoplastic processes.

Observation:

  • A unique case of multicentric peripheral ossifying fibroma (POF) is presented.
  • The patient, a 49-year-old female with excellent oral hygiene, exhibited lesions on both maxillary and mandibular gingiva.

Findings:

  • Histopathologic examination of multiple biopsy sites confirmed features consistent with POF.
  • The multicentric presentation is a rare phenomenon for this type of lesion.

Implications:

  • This case suggests a previously unrecognized multicentric variant of POF.

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  • The multifocal nature may indicate an underlying genetic predisposition to gingival soft tissue overgrowths.