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Systemic mastocytosis simulating osseous metastatic disease

Georgia Metzgeroth1, Dietmar Dinter, Philipp Erben

  • 1III. Medizinische Universitätsklinik, Universit of Heidelberg, Mannheim, Germany.

British Journal of Haematology
|January 16, 2007
PubMed
Summary

No abstract available in PubMed .

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

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