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Primary systemic amyloidosis presenting as extensive cutaneous ulceration.

Mohammed Alhaddab¹, Herbert Srolovitz, Nathan Rosen

¹Department of Dermatology, McGill University Health Centre, Montreal, QC, Canada. malhaddab@yahoo.ca

Journal of Cutaneous Medicine and Surgery

|January 20, 2007

Summary

Primary systemic amyloidosis rarely presents as a nonhealing skin ulcer. This unusual cutaneous manifestation indicated widespread organ involvement and a grave prognosis, with the patient passing away shortly after diagnosis.

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Area of Science:

Dermatology
Pathology
Internal Medicine

Background:

Primary systemic amyloidosis is a rare condition characterized by amyloid protein deposition in organs.
Cutaneous manifestations are uncommon presenting signs of this systemic disease.

Observation:

A 78-year-old woman presented with a 3-month nonhealing ulcer on her right thigh.
Histopathology revealed amorphous eosinophilic material in dermal and subcutaneous vessels, consistent with amyloid deposition.

Findings:

The case highlights an unusual presentation of primary systemic amyloidosis.
Cutaneous lesions served as the initial indicator of widespread multiorgan amyloid infiltration.

Implications:

This presentation may signify an advanced stage of the disease with a poor prognosis.
Early recognition of atypical cutaneous signs is crucial for timely diagnosis and management of systemic amyloidosis.