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Etiological spectrum of post-transfusion hepatitis
Gastroenterology
|December 1, 1975
Summary
Post-transfusion hepatitis remains common, often unrelated to hepatitis B virus (HBV). Current tests cannot identify the cause of most non-B hepatitis cases, necessitating further research into new infectious agents.
Area of Science:
- Hepatology
- Infectious Diseases
- Transfusion Medicine
Background:
- Post-transfusion hepatitis (PTH) persists despite hepatitis B virus (HBV) screening and exclusion of commercial donors.
- The majority of PTH cases are not attributed to known hepatitis viruses.
Purpose of the Study:
- To investigate the causative agents of PTH in cardiac surgery patients.
- To determine the role of hepatitis A virus (HAV), Epstein-Barr virus (EBV), and cytomegalovirus (CMV) in non-B PTH.
Main Methods:
- Serological screening for hepatitis B, A, Epstein-Barr, and cytomegalovirus.
- Analysis of preoperative, acute, and convalescent sera from 34 cardiac surgery patients with PTH.
Main Results:
- Four patients showed evidence of hepatitis B infection.
- Three patients had significant antibody titer rises to cytomegalovirus (CMV).
- No evidence of acute hepatitis A (HAV) or Epstein-Barr virus (EBV) infection was found.
Conclusions:
- Hepatitis A, Epstein-Barr, and cytomegalovirus do not explain most non-B PTH cases.
- Additional hepatitis-producing agents require identification to understand and prevent PTH.
- Further research is crucial for defining PTH epidemiology and prevention strategies.
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