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Updated: Jul 17, 2026

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
Published on: March 11, 2014
[Natural history of papillomavirus infections]
Christiane Mougin1, Lingzhao Mo, Véronique Dalstein
1EA3181, IFR 133, université de Franche-Comté, laboratoire de biologie cellulaire et moléculaire, CHU Jean-Minjoz, 25030 Besançon. christiane.mougin@univ-fcomte.fr
Abstract:
The human papillomavirus (HPV) origin of cervical cancer has been suggested by H. zur Hausen in 1976 and then confirmed by fundamental and epidemiological studies. Indeed, the proportion of invasive cervical cancers found to contain high risk HPV DNA reached more than 95%, the HPV negative women being not risky. The progression of dysplastic lesions is closely linked to the persistence of viral infection. The determinants affecting persistence of HPV infection can be divided into viral factors (types and variants, viral load, viral DNA integration and viral E6/E7 mRNA expression), host-related factors (immune response, genetic susceptibility) and environmental factors (oral contraceptive, smoking, diet).
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