Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
Pulmonary Edema II: Pathophysiology01:18

Pulmonary Edema II: Pathophysiology

Pulmonary edema is the accumulation of fluid in the interstitial and alveolar spaces of the lungs, impairing gas exchange and oxygen delivery. It may be cardiogenic or noncardiogenic, but both reduce oxygenation and lung compliance.Cardiogenic Pulmonary EdemaCardiogenic edema results from increased hydrostatic pressure in pulmonary capillaries, usually due to left ventricular dysfunction from myocardial infarction, heart failure, or valvular disease. Ineffective cardiac pumping causes blood to...
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Long-COVID, severe course, with congenital bronchiectasis, Williams-Campbell syndrome. Case report].

Terapevticheskii arkhiv·2024
Same author

[Nonimmunogenic staphylokinase in the treatment of acute ischemic stroke (FRIDA trial results)].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2022
Same author

[Chronic prostatitis, benign prostatic hyperplasia and immunity: the disorders and correction].

Urologiia (Moscow, Russia : 1999)·2013
Same author

[Relations between red cell structure, function and immune homeostasis in prostatic diseases].

Urologiia (Moscow, Russia : 1999)·2012
Same author

[Correction of immunometabolic disorders in chronic bacterial prostatitis].

Urologiia (Moscow, Russia : 1999)·2012
Same author

[Correction of complement system failure in patients with chronic prostatitis].

Urologiia (Moscow, Russia : 1999)·2011

Related Experiment Video

Updated: Jul 17, 2026

A Model of Reverse Vascular Remodeling in Pulmonary Hypertension Due to Left Heart Disease by Aortic Debanding in Rats
07:41

A Model of Reverse Vascular Remodeling in Pulmonary Hypertension Due to Left Heart Disease by Aortic Debanding in Rats

Published on: March 1, 2022

[Endothelial dysfunction mediators in patients with chronic cor pulmonale].

S A Pribylov, A I Konoplia, S A Sirotkin

    Klinicheskaia Meditsina
    |January 25, 2007
    PubMed
    Summary

    Endothelial dysfunction plays a key role in the development of pulmonary hypertension and chronic cor pulmonale. This review analyzes vasoactive mediators involved in these conditions.

    More Related Videos

    Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction
    08:35

    Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction

    Published on: August 17, 2022

    Right Ventricular Systolic Pressure Measurements in Combination with Harvest of Lung and Immune Tissue Samples in Mice
    10:20

    Right Ventricular Systolic Pressure Measurements in Combination with Harvest of Lung and Immune Tissue Samples in Mice

    Published on: January 16, 2013

    Related Experiment Videos

    Last Updated: Jul 17, 2026

    A Model of Reverse Vascular Remodeling in Pulmonary Hypertension Due to Left Heart Disease by Aortic Debanding in Rats
    07:41

    A Model of Reverse Vascular Remodeling in Pulmonary Hypertension Due to Left Heart Disease by Aortic Debanding in Rats

    Published on: March 1, 2022

    Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction
    08:35

    Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction

    Published on: August 17, 2022

    Right Ventricular Systolic Pressure Measurements in Combination with Harvest of Lung and Immune Tissue Samples in Mice
    10:20

    Right Ventricular Systolic Pressure Measurements in Combination with Harvest of Lung and Immune Tissue Samples in Mice

    Published on: January 16, 2013

    Area of Science:

    • Cardiovascular Medicine
    • Respiratory Medicine
    • Vascular Biology

    Context:

    • Pulmonary hypertension (PH) and chronic cor pulmonale are serious conditions characterized by high blood pressure in the pulmonary arteries and right heart failure.
    • Endothelial dysfunction, a condition where the endothelium (inner lining of blood vessels) does not function properly, is increasingly recognized as a critical factor in the pathogenesis of PH and chronic cor pulmonale.

    Purpose:

    • To review and synthesize current literature on the role of endothelial dysfunction in the development of pulmonary hypertension and chronic cor pulmonale.
    • To present data on endothelium-dependent vasoactive mediators implicated in these cardiovascular and respiratory diseases.

    Summary:

    • A comprehensive analysis of 49 sources from Russian and international literature was conducted.
    • The review highlights the significant contribution of endothelial dysfunction to the progression of pulmonary hypertension and chronic cor pulmonale.
    • Key endothelium-dependent vasoactive mediators and their influence on vascular tone and remodeling in the pulmonary circulation are discussed.

    Impact:

    • Provides a consolidated overview of the complex interplay between endothelial function and the development of pulmonary hypertension and chronic cor pulmonale.
    • Offers valuable insights for researchers and clinicians investigating therapeutic strategies targeting endothelial pathways.
    • Contributes to a better understanding of the pathophysiology of these debilitating conditions, potentially leading to improved patient outcomes.