Related Experiment Video
Updated: May 30, 2026

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
Published on: May 10, 2024
[Functional activity of peritoneal macrophages in acute destructive pancreatitis: evaluation, implication]
Abstract:
According to the etiology of acute pancreatitis, the authors identified the most common phenotypes of superficial antigens of peritoneal macrophages: CD14(+) CD25(-)CD64(-)HLA-DR(-) in acute biliary pancreatitis, CD14(+) CD25(+)CD64(+)HLA-DR(+) in nonbiliary pancreatitis; moreover, all the patients were found to have increased expression of early (CD25+) and late (HLA-DR+) markers of cell activation. A comparative study was conducted and the most informative tools to evaluate the adhesive, cytokine-producing, phagocytic, and oxygen-dependent activities of peritoneal macrophages were recognized.
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Acute Pancreatitis II: Pathophysiology
Acute Pancreatitis I: Introduction
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute Pancreatitis I: Introduction
Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
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