Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Small-molecule screening: advances in microarraying and cell-imaging technologies.

Rebecca L Nicholson1, Martin Welch, Mark Ladlow

  • 1Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, United Kingdom.

ACS Chemical Biology
|January 25, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Peptide Marriages: Modular Assembly of Multi-Agonist Therapeutics.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same author

Multicomponent Stapling of Glucagon-Like Peptide-1 Enables Receptor-Guided PROTAC Delivery.

Angewandte Chemie (International ed. in English)·2026
Same author

Boosting peptide half-life: enabling efficient generation of Fc-peptide conjugates.

Chemical science·2026
Same author

On-resin assembly of cysteine-reactive linkers for controlled site-selective antibody bioconjugation.

Nature protocols·2026
Same author

Targeting a Pleckstrin Homology Domain with a Lysine-Reactive Covalent Binder.

Journal of medicinal chemistry·2026
Same author

Towards the targeted protein degradation of CK2: design and synthesis of CAM4066-based PROTACs.

Beilstein journal of organic chemistry·2026
Same journal

Inositol Thiophosphates as Inhibitors of Mammalian, Plant, and Fungal Phytases.

ACS chemical biology·2026
Same journal

Synthesis and Characterization of the Spectroscopic and Imaging Utilities of Two Indole-Based Cyan Fluorescent Nucleoside Analogues.

ACS chemical biology·2026
Same journal

Indole Ring Expansion and Rearrangement-Enabled Quinoline Scaffold Formation in the Biosynthesis of the Antitumor Monoterpene Indole Alkaloid Camptothecin.

ACS chemical biology·2026
Same journal

Intracellular Delivery of Peptides and Proteins with an Engineered Membrane Translocation Domain.

ACS chemical biology·2026
Same journal

Development of Next-Generation Fluoroacetamidine-Containing Activity-Based Probes for the Selective Labeling of the Protein Arginine Deiminases (PADs).

ACS chemical biology·2026
Same journal

Spectroelectrochemical Insight into Reaction Mechanisms of Cell-Penetrating Peptides on Charged Membrane Surfaces.

ACS chemical biology·2026
See all related articles

Small molecules offer precise control over protein function. Emerging microarray and high-content screening technologies accelerate the discovery of these essential chemical probes for biological research.

Area of Science:

  • Biochemistry and Molecular Biology
  • Chemical Biology
  • Drug Discovery

Background:

  • Cell-permeable small molecules enable precise, rapid, and reversible modulation of protein function.
  • Identifying effective small-molecule probes often necessitates screening vast chemical libraries.
  • Advancements in screening technologies have made high-throughput screening more accessible.

Purpose of the Study:

  • To review emerging technologies for small-molecule screening.
  • To highlight the utility of microarray and high-content screening platforms.
  • To discuss the application of these technologies in identifying chemical probes.

Main Methods:

  • Focus on microarray screening platforms.
  • Discussion of high-content screening formats.

Related Experiment Videos

  • Review of technological advancements in chemical probe identification.

    • Main Results:

    • Emerging technologies significantly enhance the efficiency of small-molecule screening.
    • Microarray and high-content screening offer powerful tools for probe discovery.
    • These platforms facilitate temporal and quantitative control of biological systems.

    Conclusions:

    • Advanced screening platforms are revolutionizing the identification of chemical probes.
    • Microarray and high-content screening are key technologies for modulating protein function.
    • These methods provide critical tools for biological systems research and drug discovery.