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Lymphoplasmacyte-rich meningioma with atypical invasive nature

Hidenori Nohara1, Kazuhide Furuya, Nobutaka Kawahara

  • 1Department of Neurosurgery, University of Tokyo Hospital, Tokyo, Japan.

Neurologia Medico-Chirurgica
|January 25, 2007
PubMed

Insights

A rare lymphoplasmacyte-rich meningioma invaded brain tissue despite its benign grade. High Ki-67 and PET uptake suggest an atypical, aggressive nature requiring further investigation.

Area of Science:

  • Neuro-oncology
  • Pathology
  • Medical Imaging

Background:

  • Lymphoplasmacyte-rich (LPR) meningiomas are rare tumors.
  • Understanding their behavior is crucial for patient management.

Observation:

  • A 12-year-old boy presented with a posterior fossa LPR meningioma.
  • The tumor demonstrated subtotal removal with invasion into normal brain tissue.
  • Histological examination revealed a high Ki-67 staining index (MIB-1).
  • (18)F-2-fluoro-2-deoxy-D-glucose positron emission tomography showed high tumor uptake.

Findings:

  • Despite a benign World Health Organization grade, the LPR meningioma exhibited aggressive features.
  • Invasion into adjacent brain tissue was noted.
  • Elevated Ki-67 index and high FDG uptake indicate increased cellular proliferation and metabolic activity.

Implications:

  • These findings suggest LPR meningiomas can possess atypical and aggressive characteristics.
  • Further research is needed to understand the behavior and optimal treatment strategies for these tumors.
  • This case highlights the importance of comprehensive histopathological and imaging evaluation for accurate tumor grading and prognosis.

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