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Related Experiment Videos

NK/T-cell lymphoma in AIDS.

G A D'Souza1, R Sunad, Nirmala Rajagopalan

  • 1Division of Chest Medicine, Freedom Foundation, 180 Hennur Cross, Bangalore 560043, Karnataka, India.

The Journal of the Association of Physicians of India
|January 26, 2007
PubMed
Summary
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A patient with HIV experienced double vision and eyelid drooping due to an unusual presentation of NK/T cell lymphoma. This lymphoma manifested as a mass in the sinus, impacting cranial nerves.

Area of Science:

  • Neurology
  • Oncology
  • Infectious Diseases

Background:

  • Human Immunodeficiency Virus (HIV) infection can lead to various neurological complications.
  • Highly Active Antiretroviral Treatment (HAART) has significantly improved outcomes for HIV patients.
  • Ocular and cranial nerve palsies can be indicative of underlying systemic diseases.

Observation:

  • A 42-year-old male, diagnosed with HIV and on HAART, presented with diplopia and left ptosis.
  • Clinical examination revealed left 3rd cranial nerve palsy and partial right lower motor neuron facial palsy.
  • Computed Tomography (CT) of the paranasal sinuses (PNS) showed soft tissue within the right maxillary sinus antrum.

Findings:

  • The patient's symptoms were attributed to a mass identified in the maxillary sinus.

Related Experiment Videos

  • Histopathological analysis confirmed the mass to be an Extranodal Natural Killer T-cell Lymphoma (NK/T cell lymphoma).
  • This case highlights an atypical presentation of NK/T cell lymphoma in an HIV-positive individual.

    • Implications:

    • Early detection and diagnosis of unusual lymphoma presentations are crucial in immunocompromised patients.
    • Neurological symptoms in HIV-positive individuals warrant comprehensive investigation beyond opportunistic infections.
    • Maxillary sinus masses should be considered in the differential diagnosis of cranial nerve palsies, particularly in at-risk populations.